Job Description

CSL is a company that fosters a work culture emphasising Superior Performance, Innovation, Integrity, Collaboration, and Patient Focus with a commitment to support, train, and grow its people. As a leader in the biopharmaceutical industry, CSL is a multinational ASX Listed Company that is actively growing its Australian-based manufacturing operations to support global growth. CSL develops, manufactures, and markets products to treat and prevent serious human medical conditions and is globally one of the largest manufacturers of plasma-derived therapies.

The Opportunity

We are seeking an experienced Research Scientist to join the In vivo Pharmacology Group at CSL’s Melbourne-based research site at Bio21. The In vivo Pharmacology Group is responsible for evaluating and understanding the mechanism of action of protein-based therapeutics in animal models of disease.

You will support studies across a number of Immunology and Transplant related projects and will report to the In vivo Pharmacology Transplant Lead Senior Scientist within the Research Department. You will supervise a small team of scientists and work with an extended In vivo Pharmacology team supporting CSL’s other therapeutic areas.

You will be responsible for developing, performing, and supervising animal models of Hematopoietic Stem Cell Transplantation as well as overseeing studies in other transplant-related fields of interest such as solid-organ-transplant, graft-versus-host-disease, and transplant tolerance.

Your Responsibilities

• Provide scientific and technical leadership for the design, planning, execution, and analysis of animal experiments to assess in vivo efficacy, mechanism of action, safety, and PK/PD profiles of novel therapeutics.
• Present research plans and data in project teams and to research and therapeutic area senior leadership as required.
• Ensure laboratory practices and animal ethics submissions meet deadlines and comply with all relevant guidelines, standards and regulations.
• Contribute to the Transplant therapeutic area research team with active surveillance of scientific literature, provide subject matter expertise, generate new project ideas, identification of appropriate collaborators and contribution to new product opportunity evaluations and due diligences.
• Oversee and manage external collaborations.
• Support multiple pre-clinical research projects in the transplant therapeutic area.

Your Skills and Experience

• PhD and more than 5 years post-doctoral or industry experience in one or more of the following fields: Hematopoietic Stem Cell Biology and/or Transplantation, in vivo animal models to support the analysis of gene and/or cellular therapies, bone marrow conditioning, graft-versus-host disease and solid organ transplant.
• Prior experience in development and use of humanized mouse models.
• Expertise with in vivo animal models to support the assessment of HSC engraftment, gene modifications, hematopoietic immune reconstitution and/or graft-versus-host-disease.
• Expertise in gene therapy delivery systems (viral/non-viral) to support in vivo validation in animal models.
• Proficiency with standard in vivo techniques in rodents, including multiple dosing and sampling routes, as well as breeding/colony maintenance and animal ethics.
• Be able to troubleshoot research studies, proposing creative solutions.
• Lead projects as the principal scientist with the ability to advocate and influence in dynamic project team environments.
• Expertise in the complement system will be viewed as highly valuable

Apply now to join a values-based, purpose-driven company committed to protecting public health!

Applications must address the selection criteria above and include a current CV and cover letter.

Applications Close 12 March 2023

About Us

Our Benefits

We encourage you to make your well-being a priority. It’s important and so are you. Learn more about how we care at CSL.

CSL is a leading global biotechnology company with a dynamic portfolio of life-saving medicines, including those that treat haemophilia and immune deficiencies, as well as vaccines to prevent influenza. Since our start in 1916, we have been driven by our promise to save lives through innovation. Learn more about CSL.

As a global organisation with employees in 35+ countries, CSL embraces diversity, equity and inclusion. Learn more about Diversity, Equity & Inclusion at CSL.