We have an opportunity for a Senior Scientist who has a good understanding and experience of high throughput recombinant protein engineering and production in relation to biologics discovery.  In this role you will be responsible for producing protein therapeutics in a high throughput automated process, setting up and running automated processes for DNA production, transfections, purifications and QC of final protein biologics at a high throughput scale.

ABOUT ASTRAZENECA

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

SITE DESCRIPTION

Welcome to Granta Park, Cambridge (UK), one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…Cambridge is one of the most exciting bioscience hotspots in the world and plays a central role in our mission to deliver life-changing medicines to patients. Granta Park has a gym, nursery and central restaurant/coffee place as part of the science park facilities that are accessible to our staff. We also have our own bistro and deli in the AZ buildings. There are regular lunch & learn events including running clubs and after work socials on the last Friday of every month. This is our biggest and most spacious lab site with easy access from all major routes and ample car parking available - come and join us! Please be aware that towards the end of 2022 you will be required to move to the our new state-of-the-art Discovery Centre (DISC) located on the Cambridge Biomedical Campus.

BUSINESS AREA

Biologics Engineering is responsible for the discovery and optimisation of biological candidate drugs to support all therapy area drug discovery pipelines and for the development of in-house biologics discovery platforms and novel drug modalities to support future drug discovery efforts. Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, challenging accepted norms, quick decision-making and taking smart risks. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and redefine Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our grasp.

What you’ll do

• Generate recombinant expression vectors and nucleic acid preparations to allow for protein expression, particularly in relation to antibody and next-generation biologics development at a high-throughput scale

• Perform automated recombinant protein expression, using mammalian expression systems, purification (e.g. automated bead capture) and characterisation (e.g. SDS-PAGE, HPLC-SEC, Octet BLI)

• Analyse data, making detailed observations and interpretation of results and understand the implications of the data in relation to the drug discovery process.

• Demonstrate professional interpersonal communication by establishing good working relationships with team and department members and others within the company

• Ability to work effectively and collaboratively in a multi-disciplinary team and works closely with other scientists in relation to day to day working

• Understands and applies principles, theories and techniques used in cloning, expression & purification of protein biologics, to support drug and technology projects, with a high level of attention to detail and providing solutions to a variety of process related problems

• Pro-actively contributes to development of new or improved high throughput protein expression processes

• Prepares appropriate documentation such as electronic laboratory notebooks, contributions to patents and IND reports and conducts work according to current codes of practice (health and safety legislation, etc.) and all other relevant internal AstraZeneca standards and external regulations

• Presents clear and concise findings at internal (intra- and inter-departmental) project team and community of practice meetings

• Demonstrates strong interpersonal communications by establishing and using working relationships with colleagues in global Biologics Engineering and other departments

• Provides training for students or members of department in processes, where necessary

Essential for the role

• PhD with proven experience or BSc/higher degree with extensive lab-based experience

• Experience in designing and conducting laboratory experiments and processes within the field of molecular biology & protein expression.

• Proven track record of running and trouble-shooting high-throughput automated liquid handling systems e.g. Hamilton platforms.

• Experienced scientist capable of proactively contributing to development of new or improved processes.

• Strong professional communication skills and excellent attention to detail, capable of developing good working relationships with diverse individuals across organisational boundaries and experience working within a team environment

• Has scientific curiosity and proactively develops knowledge

• Acts with integrity and does the right thing

Desirable for the role

• Background in drug discovery and development in the pharmaceutical industry

• Ability to write code and script automation platforms

• Knowledge of antibodies and related therapeutic modalities

Competitive salary & benefits

Close date: 25/07/2022

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next?

• Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

• Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

• If you’re curious to know more then please reach out to Louise Bennett

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

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Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.